Valproic acid (VPA)

Description

"Valproic Acid is a synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)" Source: NCIt

structure, image from PubChem

Alternative names

• 2-Propylpentanoic acid
• 99-66-1
• Dipropylacetic acid
• 2-Propylvaleric acid

References

• Rao and LaBonne 2018
• NCBI PubChem CID:3121

> 84 Xenbase articles contain a reference to Valproic acid according to textpresso

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