XB-FEAT-984984

col5a3

This is the community wiki page for the gene col5a3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

annotation notes

08AUG2025 True col5a3 orthologs are on Xenopus chromsomes chr3/3L3S. The wrong Xtropicalis gene model was posted on this genepage, which was accually Xtrop col11a1. It has been moved to XB-GENE-22063043, the col11a1 gene page. I have now posted the 'missing' X.trop model here. Please note that the associated accessions (proteins mRna etc) will take at least 1 db refresh cyle to switch between gene pages. Apologies if this causes problems for you!.

summary for human COL5A3 from NCBI

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]