XB-FEAT-6257735

lrrc51

This is the community wiki page for the gene lrrc51 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

16ARP2026

Xenopus gene symbol and name changed from lrtomt, leucine rich transmembrane and O-methyltransferase domain containing to lrrc51, leucine rich repeat containing 51 following request by RefSeq. Apparently this was misannotated in v10.

The encoded 190 aa protein represented on this locus is an ortholog of human LRRC51, not LRTOMT.

The 190 aa protein encoded by NP_989055 contains leucine rich repeats and aligns well with human NP_001305732.1 from LRRC51 (GeneID:120356739), and does not the tRNA 5-hydroxyU34 O-methylase TrmR/YrrM domain structure found in tomt genes.

In human, there is a readthrough between the LRRC51 and TOMT genes that has the LRTOMT nomenclature and has the same CDS as TOMT, but uses the 5' terminal exon that is the same as LRRC51. In X. tropicalis, the two loci are completely independent.

summary for human LRRC51 from NCBI

This gene belongs to the leucine-rich repeat containing family. The encoded protein contains a transmembrane domain and two leucine-rich repeat domains. Unlike in mouse and other mammals, readthrough transcription is observed in primates between this gene and the adjacent transmembrane O-methyltransferase (Tomt) gene. Previously, this locus was annotated as a single gene representing the readthrough transcripts as well as the two different transcript species that encoded different proteins. It has since been split into three genes, including the two stand-alone genes and a third gene representing the readthrough transcription. [provided by RefSeq, Feb 2022]