XB-FEAT-5884885
(Redirected from Mul1)
LOC100487584
This is the community wiki page for the gene LOC100487584 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
13APR2026
X. tropicalis GeneID: 100487584 (XB-GENE-5884886) name changed from mul1, mitochondrial E3 ubiquitin protein ligase 1 to LOC 10048758 following assessment by NCBI RefSeq curators.
See notes below:
In looking at these loci, it is actually GeneID:116412398 (XB-GENE-29098715) which is the ortholog of human MUL1, not GeneID: 100487584 (XB-GENE-5884886).
These two loci are in tail-to-tail configuration. The genomic sequence of GeneID:116412398 (XB-GENE-29098715) supports a 350 aa protein that shares 60% identity (77% similarity) and aligns well across the entire human 349 aa protein. It is supported by transcripts such as CF783801.1 with strong RNA-seq and intron structure support. It is now being represented by NM_001445355.1, encoding the 350 aa protein.
This is in contrast to GeneID: 100487584 (XB-GENE-5884886), where the genome does not support the protein and has a corrected model XM_. This locus has no transcripts that align to the putative CDS and it is unclear if this locus actually represents a protein coding gene.