XB-FEAT-1010760

ogdh

This is the community wiki page for the gene ogdh please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

11/07/2016

Human name has changed for Entrez Gene: 4967. From oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) to oxoglutarate dehydrogenase

summary from NCBi for human OGDH

OGDH - oxoglutarate dehydrogenase

This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]