XB-FEAT-951876

sec14l2

This is the community wiki page for the gene sec14l2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature updates

19MAY2026 Xenopus gene nomenclature was updated, changing from s'ec14l3, SEC14-like lipid binding 3 to sec14l2, SEC14 like lipid binding 2. THis is supported by synteny with human and otehr vertebrates.

summary for human SEC14L2 from NCBI

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]