XB-FEAT-1011627

tcf4

This is the community wiki page for the Xenopus tcf4 genes. Please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

annotation notes

1.8.20 entrez 108718448 added to tcf4.L

1.9.20 gene45528 model added to tcf4.L

summary from NCBI for human TCF4

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]